Cardiff University Cardiff, Cardiff County
Summary Is Huntington's Disease a complex trait ? Hitherto, susceptibility to Huntington's Disease (HD) has been assumed to be due to the effects of a single gene. However, our latest results show that several genes modify age at onset in HD (https://www.biorxiv.org/content/10.1101/529768v1). We have an exciting opportunity to appoint an enthusiastic statistical geneticist to the Huntington's disease (HD) genetics research team at Cardiff University. The post holder will use state-of-the art analysis techniques to analyse large genetic datasets (GWAS and sequencing) to identify novel genetic susceptibility loci and pathways that modify the phenotypic expression of HD (age at onset and other symptoms), and their overlap with other neuropsychiatric disorders. The successful applicant will thus have the opportunity to take part in cutting-edge research investigating the complex architecture of Huntington's disease modifiers and potentially leading to the development of novel therapeutic treatments. The role holder will work independently and as part of a multi-disciplinary team, to perform self-directed analyses using in house and publicly available datasets for high impact, peer-reviewed publications. Applicants should be knowledgeable and enthusiastic with the ability to multi-task and communicate effectively. Core tasks will include data analysis and management of large genome-wide SNP and next generation sequencing datasets generated in house and with collaborators. Collaborative working is a key component of this role meaning that communication skills will be vital, in order to build links and cultivate international collaborations with a number of academic institutions. The successful applicant will be based in the MRC Centre for Neuropsychiatric Genetics and Genomics (https://www.cardiff.ac.uk/mrc-centre-neuropsychiatric-genetics-genomics) with close links to the recently awarded Dementia Research Institute (https://www.cardiff.ac.uk/dementia-research-institute).This will ensure that the applicant has exposure to cutting-edge research in a variety of fields, and also has access to training as required. The successful applicant will have a PhD in statistical genetics, bioinformatics, mathematics, statistics or computing or equivalent industrial experience, with proven experience in the statistical analysis of large genetic datasets. Expert knowledge of data manipulation in a UNIX/Linux environment and proficiency in high level programming languages such as Perl, Python, or C++ is essential, as is knowledge of statistical techniques used in genetics and epidemiology, as well as experience in using relevant software packages, such as PLINK. Knowledge of bioinformatic data and analysis techniques is desirable. For further details, please contact Prof. Peter Holmans ([email protected]). The post is full-time (35 hours), available from 1st May 2019 and is fixed term for 24 months. Salary: £42,036 - £48,677 per annum (Grade 7) Date advert posted: Friday, 29 March 2019 Closing date: Friday, 19 April 2019 Please be aware that Cardiff University reserves the right to close this vacancy early should sufficient applications be received. Cardiff University is committed to supporting and promoting equality and diversity and to creating an inclusive working environment. We believe this can be achieved through attracting, developing, and retaining a diverse range of staff from many different backgrounds who have the ambition to create a University which seeks to fulfil our social, cultural and economic obligation to Cardiff, Wales, and the world. In supporting our employees to achieve a balance between their work and their personal lives, we will also consider proposals for flexible working or job share arrangements.